Apelin Receptor (APJ)
Apelin receptor (APJ) is a member of the family A of G-protein-coupled receptors (GPCRs) and Apelin is an endogenous ligand for an APJ that was previously isolated from bovine stomachs. Apelin is a 77-amino acid precursor protein that is hydrolysed to produce active peptides of different lengths, such as Apelin-36, Apelin-31, Apelin-17, and Apelin13. The apelin/APJ system plays important roles in the physiology and pathophysiology of several organs, including regulation of fluid homeostasis, blood pressure, cardiac contractility, angiogenesis, metabolic balance, and cell proliferation, apoptosis, or inflammation. Additionally, the apelin/APJ system is widely expressed in the central nervous system, especially in neurons and oligodendrocytes. APJ is also involved in anxiety, and depression.
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Apelin Receptor (APJ) Related Products (57)
Related Products (57)
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Apelin-12
0 ImagesApelin-12 is one of the most potent C-terminal fragments of the polypeptide that possesses a high affinity to orphan receptor APJ receptor. Apelin-12 is involved in the regulation of body fluid homeostasis and in the central control of feeding. Apelin-12 blocks HIV-1 entry through APJ receptor. Apelin-12 exerts neuroprotective effect.
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Elabela(19-32) TFA
0 ImagesCat. No.: HY-P2106APurity: 99.93%Elabela(19-32) TFA is an active fragment of ELABELA (ELA) that binds to apelin receptor (APJ). Elabela(19-32) TFA activates the Gαi1 and β-arrestin-2 signaling pathways with EC50s of 8.6 nM and 166 nM. Elabela(19-32) TFA induces receptor internalization and reduces arterial pressure, exerts positive inotropic effects on the heart.
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1-Methyl-3-phenylpropylamine
0 ImagesSynonyms: 4-Phenylbutan-2-amineELA-32(human) is a potent critical cardiac developmental peptide that acts through the G-protein–coupled apelin receptor.
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ELA-11(human)
0 ImagesELA-11(human), a peptide, is a full agonist of human apelin receptor, with a pKi of 7.85. ELA-11(human) completely inhibits Forskolin-induced cAMP production and stimulates β-arrestin recruitment.
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(2R,3S)-Azelaprag
0 ImagesSynonyms: (2R,3S)-AMG 986(2R,3S)-Azelaprag ((2R,3S)-AMG 986) (Example 238.0) is a precursor of an apelin receptor agonist (EC50=12 nM) and an isomer of Azelaprag (HY-109111).
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ELA-21 (human)
0 ImagesELA-21 (human) is an apelin receptor agonist with a pKi of 8.52. ELA-21 (human) completely inhibits Forskolin-induced cAMP production and stimulates β-arrestin recruitment with subnanomolar potencies. ELA-21 (human) is an agonist in G-protein-dependent and -independent pathways.
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Apelin-16, human, bovine acetate
0 ImagesCat. No.: HY-P5392APurity: 99.77%Apelin-16, human, bovine acetate is a biological active peptide. (Apelin is the endogenous ligand for the G-protein-coupled APJ receptor. It is produced as a pre-proprotein of 77 amino acids.Apelin-16 is one of the active fragment of Apelin).
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ELA-32(human)
0 ImagesCat. No.: HY-P2196CAS No.: 1680205-79-1ELA-32 (human) is a potent critical cardiac developmental peptide that acts through the G-protein–coupled apelin receptor.
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Apelin-36(human) TFA
0 ImagesCat. No.: HY-P1064APurity: 99.42%Apelin-36(human) TFA is an endogenous orphan G protein-coupled receptor APJ agonist, with an EC50 of 20 nM. Apelin-36(human) TFA shows high affinity to human APJ receptors expressed in HEK 293 cells (pIC550=8.61). Apelin-36(human) TFA has been linked to two major types of biological activities: cardiovascular and metabolic. Apelin-36(human) TFA inhibits the entry of some HIV-1 and HIV-2 into the NP2/CD4 cells expressing APJ.
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ALX 40-4C
0 ImagesCat. No.: HY-P7061CAS No.: 143413-49-4
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Apelin-16, human, bovine
0 ImagesCat. No.: HY-P5392CAS No.: 942905-20-6Apelin-16, human, bovine is a biological active peptide. (Apelin is the endogenous ligand for the G-protein-coupled APJ receptor. It is produced as a pre-proprotein of 77 amino acids.Apelin-16 is one of the active fragment of Apelin)
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ELA-11(human) TFA
0 ImagesCat. No.: HY-P2197AELA-11(human) TFA is a high affinity apelin receptor agonist (Ki=14 nM). ELA-11(human) TFA is a bioactive fragment of ELA-32. ELA-11(human) TFA inhibits forskolin-induced cAMP production and stimulates β-arrestin recruitment in vitro.
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APJ receptor agonist 10
0 ImagesAPJ receptor agonist 10 is an agonist of the APJ Receptor. APJ receptor agonist 10 can be used for research on pulmonary arterial hypertension.
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APJ receptor agonist 5
0 ImagesCat. No.: HY-145285CAS No.: 2135514-20-2APJ receptor agonist 5 (compound 3) is a potent and orally active agonist of apelin receptor (APJ) with an EC50 of 0.4 nM. APJ receptor agonist 5 displays excellent pharmacokinetic profiles in the rodent heart failure (HF) model. APJ receptor agonist 5 also shows an acceptable safety profile in preclinical toxicology studies. APJ receptor agonist 5 leads to improved cardiac function and can be used for researching the HF disease.
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APJ receptor agonist 3
0 ImagesCat. No.: HY-139876CAS No.: 2759159-56-1APJ receptor agonist 3 is a potent and orally active APJ receptor agonist with an EC50 value of 0.027 nM.
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APJ receptor agonist 10 free base
0 ImagesAPJ receptor agonist 10 free base is an agonist of the APJ Receptor. APJ receptor agonist 10 free base can be used for research on pulmonary arterial hypertension.
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Apelin agonist 1
0 ImagesCat. No.: HY-126293CAS No.: 2227512-85-6Apelin agonist 1 is an oral selective apelin agonist AM-2995, a agonist of the APJ (APLNR, angiotensin receptor like-1) receptor, may be used in the treatment of cardiovascular conditions. Apelin agonist 1 is extracted from patent WO 2018097944 (210.0), Example 210.0.
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NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal)
![NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal)](https://file.medchemexpress.com/product_pic/hy-p3346.gif "Click to View NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal) Product Detail")
0 ImagesCat. No.: HY-P3346CAS No.: 2891469-80-8NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal) (compound 39) is a potent APJ agonist, with a Ki of 0.6 nM. NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal) can activate Gαi1 (EC50=0.8 nM) and recruit β-arrestin2 (EC50=31 nM). NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal) exhibits prolonged cardiac effects.
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APJ receptor agonist 6
0 ImagesCat. No.: HY-147751CAS No.: 1965244-85-2APJ receptor agonist 6 (compound 9) is a potent APJ (apelin receptor) agonist, with Ki of 1.3 μM. APJ receptor agonist 6 has EC50 values of 0.070 , 0.097, and 0.063 μM for calcium, cAMP, and β-arrestin, respectively.
